Comprehensive Functional Analysis of N-Linked Glycans on Ebola Virus GP1

  title={Comprehensive Functional Analysis of N-Linked Glycans on Ebola Virus GP1},
  author={Nicholas J Lennemann and Bethany A. Rhein and Esther Ndungo and Kartik Chandran and Xiangguo Qiu and Wendy J. Maury},
UNLABELLED Ebola virus (EBOV) entry requires the virion surface-associated glycoprotein (GP) that is composed of a trimer of heterodimers (GP1/GP2). The GP1 subunit contains two heavily glycosylated domains, the glycan cap and the mucin-like domain (MLD). The glycan cap contains only N-linked glycans, whereas the MLD contains both N- and O-linked glycans. Site-directed mutagenesis was performed on EBOV GP1 to systematically disrupt N-linked glycan sites to gain an understanding of their role in… CONTINUE READING
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