Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis.

@article{Guo2016ComprehensiveEV,
  title={Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis.},
  author={Yabin Guo and Barrett L. Updegraff and Seong Ho Park and Deniz Durakoglugil and Victoria H. Cruz and Sarah Maddux and Tae Hyun Hwang and Kathryn A O'donnell},
  journal={Cancer research},
  year={2016},
  volume={76 4},
  pages={
          773-86
        }
}
Aberrant signaling through cytokine receptors and their downstream signaling pathways is a major oncogenic mechanism underlying hematopoietic malignancies. To better understand how these pathways become pathologically activated and to potentially identify new drivers of hematopoietic cancers, we developed a high-throughput functional screening approach using ex vivo mutagenesis with the Sleeping Beauty transposon. We analyzed over 1,100 transposon-mutagenized pools of Ba/F3 cells, an IL3… CONTINUE READING
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Sleeping Beauty transposon integrates into non-TA dinucleotides

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