Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities.

@article{Teyra2017ComprehensiveAO,
  title={Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities.},
  author={Joan Teyra and Haiming Huang and Shobhit Jain and Xinyu Guan and Aiping Dong and Yanli Liu and Wolfram Tempel and Jinrong Min and Yufeng Tong and Philip M. Kim and Gary D. Bader and Sachdev S. Sidhu},
  journal={Structure},
  year={2017},
  volume={25 10},
  pages={1598-1610.e3}
}
SH3 domains are protein modules that mediate protein-protein interactions in many eukaryotic signal transduction pathways. The majority of SH3 domains studied thus far act by binding to proline-rich sequences in partner proteins, but a growing number of studies have revealed alternative recognition mechanisms. We have comprehensively surveyed the… CONTINUE READING