Compounds possessing Morphine-antagonizing or Powerful Analgesic Properties

@article{Bentley1965CompoundsPM,
  title={Compounds possessing Morphine-antagonizing or Powerful Analgesic Properties},
  author={Kenneth W. Bentley and Alan L.A. Boura and Alice E. Fitzgerald and David Hardy and A. Mccoubrey and Merla Aikman and Robert E. Lister},
  journal={Nature},
  year={1965},
  volume={206},
  pages={102-103}
}
Bentley and Hardy1 and Lister2 have recently described derivatives of 6,14-endoethenotetrahydrothebaine and oripavine which are highly potent analgesics in laboratory animals. One of these compounds, 6,14-endoetheno-7-α(2-hydroxypent-2-yl)-tetrahydro-oripavine (M.183), is a potent analgesic in man3. The investigation has been extended to the examination of bases with the general structure I. They were prepared by N-demethylation with cyanogen bromide and hydrolytic removal of the cyano-group… 
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