Compounds possessing 5-HT3 receptor antagonistic activity inhibit intestinal propulsion in mice.

@article{Nagakura1996CompoundsP5,
  title={Compounds possessing 5-HT3 receptor antagonistic activity inhibit intestinal propulsion in mice.},
  author={Yukinori Nagakura and Yutaka Naitoh and Takeshi Kamato and Mayumi Yamano and K. Miyata},
  journal={European journal of pharmacology},
  year={1996},
  volume={311 1},
  pages={67-72}
}
The role of 5-HT3 receptors in the control of intestinal propulsive activity was investigated in mice by a simple method in which the time taken for excretion of the head of an orally administered non-absorbable marker (whole gut transit time) was measured. Selective 5-HT3 receptor antagonists ramosetron (YM060) at 0.01-0.3 mg/kg s. c. and ondansetron at 0.1-1 mg/kg s.c. dose-dependently prolonged the whole gut transit time. Prokinetic benzamides, such as renzapride (0.3-10 mg/kg s.c… CONTINUE READING

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