Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.

@article{Cerezo2016CompoundsTE,
  title={Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.},
  author={Micha{\"e}l Cerezo and Abdelali Lehraiki and Antoine Millet and Florian Rouaud and Magali Plaisant and Emilie Jaune and Thomas Botton and Cyril Ronco and Patricia Abbe and Hella Amdouni and Thierry Passeron and V{\'e}ronique Hofman and Baharia Mograbi and Anne-Sophie Dabert-Gay and Delphine Debayle and Damien Alcor and Nabil Rabhi and Jean S{\'e}bastien Annicotte and Laurent H{\'e}liot and Mariano Gonzalez-Pisfil and Richard F. Kefford and Solange Mor{\'e}ra and Armelle Vigouroux and Philippe Gual and Maruf Mu Ali and Corine Bertolotto and Myl{\`e}ne Desch{\^e}nes and Robert Ballotti and Rachid Benhida and St{\'e}phane Rocchi},
  journal={Cancer cell},
  year={2016},
  volume={30 1},
  pages={
          183
        }
}
Graphical Abstract Highlights d HA15 is a molecule that targets specifically BiP/GRP78/ HSPA5 d HA15 induces ER stress leading to cancer cell death in vitro and in vivo d HA15 overcomes BRAF inhibitor resistance in melanoma cells d HA15 is a potential therapeutic for melanoma treatment In Brief Cerezo et al. show that HA15, the lead compound of a series of thiazole benzenesulfonamides that they have developed, kills cancer cells by targeting BiP to increase ER stress. HA15 exhibits strong… CONTINUE READING
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