Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail'.

@article{Castellani2011CompoundingAW,
  title={Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail'.},
  author={Rudy J. Castellani and Mark A. Smith},
  journal={The Journal of pathology},
  year={2011},
  volume={224 2},
  pages={147-52}
}
With each failure of anti-amyloid-β therapy in clinical trials, new trials are initiated with no hint of slowing down. This may be due, in part, to the fact that the amyloid cascade hypothesis has been so modified over time that it is now impossible to confirm or deny. The hypothesis now states, in effect, that invisible molecules target invisible structures. Still relevant, however, are multiple factors that surely cast some doubt but have either been rationalized or overlooked. Among these… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

Diagnostic uncertainty in Alzheimer’s disease : A bio-metrology perspective addressed to microRNA-based biomarkers

2018 IEEE International Symposium on Medical Measurements and Applications (MeMeA) • 2018
View 1 Excerpt

Immunotherapy and Biomarkers in Neurodegenerative Disorders

Methods in Pharmacology and Toxicology • 2016

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Neuropathological correlates of dementia in over80 year - old brain donors from the population - based Cambridge city over75 s cohort ( CC 75 C ) study

C Brayne, K Richardson, FE Matthews
J Alzheimer Dis • 2009

Similar Papers

Loading similar papers…