Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail'.

  title={Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail'.},
  author={Rudy J. Castellani and Mark A. Smith},
  journal={The Journal of pathology},
  volume={224 2},
With each failure of anti-amyloid-β therapy in clinical trials, new trials are initiated with no hint of slowing down. This may be due, in part, to the fact that the amyloid cascade hypothesis has been so modified over time that it is now impossible to confirm or deny. The hypothesis now states, in effect, that invisible molecules target invisible structures. Still relevant, however, are multiple factors that surely cast some doubt but have either been rationalized or overlooked. Among these… CONTINUE READING
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