Compound heterozygotes for filaggrin gene mutations do not always show severe atopic dermatitis.

Abstract

BACKGROUND Mutations in FLG, which encodes profilaggrin, cause ichthyosis vulgaris (IV) and are an important predisposing factor for atopic dermatitis (AD). IV shows autosomal hemidominant (semidominant) inheritance, and patients with bi-allelic FLG mutations tend to have severe IV phenotypes. However, the effect of bi-allelic FLG mutations on AD incidence… (More)
DOI: 10.1111/jdv.13871

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