Compound heterozygosity for Hb Korle-Bu (beta(73); Asp-Asn) and Hb E (beta(26); Glu-Lys) with a 3.7-kb deletional alpha-thalassemia in Thai patients.

@article{Changtrakun2002CompoundHF,
  title={Compound heterozygosity for Hb Korle-Bu (beta(73); Asp-Asn) and Hb E (beta(26); Glu-Lys) with a 3.7-kb deletional alpha-thalassemia in Thai patients.},
  author={Yossombat Changtrakun and Suthat Fucharoen and K. Ayukarn and Nirut Siriratmanawong and Goonnapa Fucharoen and Kanokwan Sanchaisuriya},
  journal={Annals of hematology},
  year={2002},
  volume={81 7},
  pages={389-93}
}
Hemoglobin (Hb) Korle-Bu (beta73; Asp-Asn) is the most frequent of the rare beta-chain variants in the population of West Africa whereas Hb E (beta26; Glu-Lys) is common among the Southeast Asian population. We report a hitherto undescribed condition in which these two beta-chain variants co-segregate. The proband was a 19-year-old Thai pregnant woman in her second trimester of pregnancy who visited our thalassemia screening unit. Cellulose acetate electrophoresis and high-performance liquid… CONTINUE READING