Compound glycyrrhizin plus conventional therapy for psoriasis vulgaris: a systematic review and meta-analysis of randomized controlled trials

@article{Yu2017CompoundGP,
  title={Compound glycyrrhizin plus conventional therapy for psoriasis vulgaris: a systematic review and meta-analysis of randomized controlled trials},
  author={Jason Jingjie Yu and Claire Shuiqing Zhang and Meaghan E. Coyle and Yiqi Du and Anthony Lin Zhang and Xin-feng Guo and Charlie Changli Xue and Chuanjian Lu},
  journal={Current Medical Research and Opinion},
  year={2017},
  volume={33},
  pages={279 - 287}
}
Abstract Background: Psoriasis vulgaris is a chronic skin condition affecting patients’ quality of life. Long-term use of conventional therapy increases risk of unwanted side effects. Compound glycyrrhizin in conjunction with conventional therapy has been used in clinical practice, but the evidence for such practice has not been evaluated systematically. Objective: This review aims to evaluate the efficacy and safety of compound glycyrrhizin in combination with conventional therapy for… 
View on Taylor & Francis
ncbi.nlm.nih.gov
30 Citations
Background Citations
6
Methods Citations
2

30 Citations

A systematic review and meta-analysis on the efficacy and safety of traditional Chinese medicine bath in the treatment of psoriasis vulgaris.
TLDR
The TCM bath had a significant effect on the treatment of psoriasis vulgaris, and the TER of the meta-analysis of treatment in this study was higher in the experimental group; the incidence of adverse reactions was lower in the Experimental group; and the area and severity of Psoriasis were lower inThe experimental group.
Treatment of psoriasis by compound glycyrrhizin injection and its effects on peripheral blood Th 17 cell proportion and IL-22 concentration
TLDR
The combination of compound glycyrrhizin and standard treatment showed good efficacy, which may be related with the decreasing of Th17 cell proportion and IL-22 levels.
The Potential of Glycyrrhizinate in the Management of COVID-19: A Systematic Review of the Efficacy and Safety of Glycyrrhizin Preparations in the Treatment of SARS and MERS.
TLDR
It is inferred that compound glycyrrhizin could be an optional therapeutic strategy for SARS-CoV-2 infections, especially those complicated with liver damage, and further research using well-designed randomized clinical trials (RCTs) is warranted to determine the dosage and duration of use of compound Glycyr rhizin and to monitor its specific adverse effects.
Issues of use of hepatoprotectors in psoriasis: Indications and effectiveness
TLDR
The inclusion of phosphogliv in the therapeutic complex can increase the effectiveness of the treatment and reduce the risk of developing druginduced liver damage against the background of the use of potentially hepatotoxic drugs.
The Gene Expression Analysis of Peripheral Blood Monocytes From Psoriasis Vulgaris Patients With Different Traditional Chinese Medicine Syndromes
TLDR
Gen expression profiling of monocytes from psoriasis vulgaris patients with different TCM syndrome types is analyzed to reveal the molecular basis of different Psoriasis syndromes and link the three syndrome at the gene level.
Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques
TLDR
It is reported that hydrogen water, an effective ROS scavenger, has significant and rapid improvement in disease severity and quality of life for patients with psoriasis and parapsoriasis en plaques.
Decoding active components in a formulation of multiple herbs for treatment of psoriasis based on three cell lines fishing and liquid chromatography-mass spectrometry analysis.
Liquorice for pain?
TLDR
Having a host of bioactive compounds with a broad range of mechanisms of effect, liquorice is a plant that, in the future, may give rise to new therapies for pain.
Clinical Evaluation of Sequential Transdermal Delivery of Vitamin B6, Compound Glycyrrhizin, Metronidazole, and Hyaluronic Acid Using Needle-Free Liquid Jet in Facial Seborrheic Dermatitis
TLDR
Sequential transdermal delivery of small molecular weight drugs (vitamin B6, glycyrrhizin compound, metronidazole, and hyaluronic acid) using NTJI is a safe, low-toxicity, and take-home drug-free therapy for the treatment of FSD.
Is There a Relationship Between Psoriasis and Hepatitis C?: a Meta-analysis and Bioinformatics Investigation
TLDR
The module and pathway enrichment analyses showed that the common genes had the potential to influence varieties of biological pathways, including the inflammatory response, cytokine activity, and cytokine–cytokine receptor interaction, Toll-like receptor signaling pathway, which play an important role in the pathogenesis of hepatitis C and psoriasis.
...
...

References

SHOWING 1-10 OF 52 REFERENCES
Oral Chinese herbal medicine combined with pharmacotherapy for psoriasis vulgaris: a systematic review
TLDR
The main plants used in these studies, Rehmannia glutinosa root, Salvia miltiorrhiza root, and Lithospermum erythrorhizon root, have shown anti‐inflammatory and/or antiproliferative effects in experimental studies and may at least partially explain the observed results.
Add-On Effect of Chinese Herbal Medicine Bath to Phototherapy for Psoriasis Vulgaris: A Systematic Review
TLDR
CHM bath appears to be a beneficial and safe adjunctive therapy to phototherapy for psoriasis vulgaris, however, these results should be interpreted with caution due to the low methodological quality of the included studies.
Clinical observation and pharmacological analysis of glycyrrhizin in treating psoriasis vulgaris
TLDR
It reaches a curative treatment for glycyrrhizin in treating psoriasis vulgaris, which correct the patient's immune disorders, and was significantly higher than that of control group.
Curative Effect Study on Acitretin A combined with compound glycyrrhizin in treating 60 cases of psoriasis vulgaris
TLDR
Acitretin A combined with compound glycyrrhizin can raise curative effect, reduce side effect of liver and kidney and adverse effect in treating psoriasis vulgaris and is a kind of safe and high-performance treatment method.
S3 – Guidelines on the treatment of psoriasis vulgaris (English version). Update
  • A. Nast, W. Boehncke, B. Rzany
  • Medicine
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • 2012
TLDR
The Guidelines focus on induction therapy in cases of mild, moderate and severe plaque‐type psoriasis in adults including systemic therapy, UV therapy and topical therapies.
The treatment of atopic dermatitis with licorice gel
TLDR
The results showed that licorice extract could be considered as an effective agent for treatment of atopic dermatitis.
Glycyrrhizin Ameliorates Imiquimod-Induced Psoriasis-like Skin Lesions in BALB/c Mice and Inhibits TNF-a-Induced ICAM-1 Expression via NF-κB/MAPK in HaCaT Cells
TLDR
It is demonstrated that GL treatment ameliorates skin inflammation by inhibiting ICAM-1 expression via interference with the ERK/p38 MAPK and NF-κB signaling pathways in keratinocytes, therefore, GL can be used as an anti-psoriasis drug.
Definition of treatment goals for moderate to severe psoriasis: a European consensus
TLDR
This programme defines the severity of plaque psoriasis for the first time using a formal consensus of 19 European experts and to improve patient care and mitigate the problem of undertreatment.
Literature analysis of reports for adverse drug reactions of compound glycyrrhizin injection
TLDR
Clinical staff should be aware of the characteristics and regularity ofADR induced by compound glycyrrhizin injection, and the use of the drug should be under strict monitoring to reduce the occurrence of ADR.
Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics.
...
...