Compositional modification of nascent in vitro dental plaques by human host-defence peptides.

@article{Madhwani2012CompositionalMO,
  title={Compositional modification of nascent in vitro dental plaques by human host-defence peptides.},
  author={Tejal Madhwani and Andrew J McBain},
  journal={FEMS immunology and medical microbiology},
  year={2012},
  volume={64 3},
  pages={
          374-81
        }
}
Salivary host-defence peptides include defensins, histatins and cathelicidin. We have investigated the effects of these peptides on the microbial composition of dental plaques. Salivary consortia, established within hydroxyapatite disc models, were exposed during development to physiological levels of human neutrophil proteins (HNP) 1 and 2; human β defensins (hβD) 1, 2 and 3; histatins (His) 5 and 8; and cathelicidin (LL37). Effects on aggregation and microbial composition were determined… CONTINUE READING
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