Compositional and material properties of rat bone after bisphosphonate and/or Strontium ranelate drug treatment.

@article{Wu2013CompositionalAM,
  title={Compositional and material properties of rat bone after bisphosphonate and/or Strontium ranelate drug treatment.},
  author={Yuchin Wu and Samer Adeeb and M. John M. Duke and David J Munoz-Paniagua and Michael R Doschak},
  journal={Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques},
  year={2013},
  volume={16 1},
  pages={52-64}
}
PURPOSE We investigated elemental strontium and/or bisphosphonate drug incorporation upon the compositional and biomechanical properties of vertebral bone, in a rat model of Osteoporosis secondary to ovariectomy. METHODS Six month old female rats were ovariectomized (OVX) and divided into untreated OVX-Vehicle, OVX-RIS (Risedronate bisphosphonate [BP] treated), OVX-SrR (Strontium Ranelate [Protos®] treated), combination OVX-RIS+SrR, and sham-operated controls. After 16 weeks of treatment… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…