Compositional analysis of glycosaminoglycans by electrospray mass spectrometry.

  title={Compositional analysis of glycosaminoglycans by electrospray mass spectrometry.},
  author={Joseph Zaia and Catherine E. Costello},
  journal={Analytical chemistry},
  volume={73 2},
The purpose of this work is to analyze glycosaminoglycans (GAGs) directly from complex mixtures without the need to purify individual components. Novel conditions for negative ion electrospray MS of chondroitin sulfate (CS) oligosaccharides are described in which sodium adduction and fragmentation are avoided. Differentiation between positional sulfation isomers is demonstrated for CS disaccharides, and a selected reaction monitoring scheme is used to quantify sulfation isomers in disaccharides… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 22 extracted citations

Cracking the Sugar Code by Mass Spectrometry

Journal of the American Society for Mass Spectrometry • 2018
View 4 Excerpts
Highly Influenced

Heparan sulfate differences in rheumatoid arthritis versus healthy sera.

Matrix biology : journal of the International Society for Matrix Biology • 2014
View 2 Excerpts

Similar Papers

Loading similar papers…