Compositional analysis of glycosaminoglycans by electrospray mass spectrometry.

@article{Zaia2001CompositionalAO,
  title={Compositional analysis of glycosaminoglycans by electrospray mass spectrometry.},
  author={Joseph Zaia and Catherine E. Costello},
  journal={Analytical chemistry},
  year={2001},
  volume={73 2},
  pages={233-9}
}
The purpose of this work is to analyze glycosaminoglycans (GAGs) directly from complex mixtures without the need to purify individual components. Novel conditions for negative ion electrospray MS of chondroitin sulfate (CS) oligosaccharides are described in which sodium adduction and fragmentation are avoided. Differentiation between positional sulfation isomers is demonstrated for CS disaccharides, and a selected reaction monitoring scheme is used to quantify sulfation isomers in disaccharides… CONTINUE READING

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