Compositional Preferences in Quadruplets of Nearest Neighbor Residues in Protein Structures : Statistical Geometry Analysis

  title={Compositional Preferences in Quadruplets of Nearest Neighbor Residues in Protein Structures : Statistical Geometry Analysis},
  author={Iosif I. Vaisman and Alexander Tropsha and Weifan Zheng},
Three-dimensional structure and amino acid sequence of proteins are related by an unknown set of rules that is often referred to as the folding code. This code is believed to be significantly influenced by nonlocal interactions between the residues. A quantitative description of nonlocal contacts requires the identification of neighboring residues. We applied statistical geometry approach to analyze the patterns of spatial proximity of residues in known protein structures. Structures from a… CONTINUE READING


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