Compositional Analysis and Metabolism of Human Milk Oligosaccharides in Infants.

@article{Kunz2017CompositionalAA,
  title={Compositional Analysis and Metabolism of Human Milk Oligosaccharides in Infants.},
  author={Clemens Kunz and Silvia Rudloff},
  journal={Nestle Nutrition Institute workshop series},
  year={2017},
  volume={88},
  pages={
          137-147
        }
}
  • C. Kunz, S. Rudloff
  • Published 2017
  • Medicine, Biology
  • Nestle Nutrition Institute workshop series
It is a great success that biotechnological means are available today to produce amounts of single human milk oligosaccharides (HMOs) in a purity which allows performing metabolic and functional studies even in humans. As recent data indicate that there is a link between the Lewis blood group and the secretor status of an individual and certain inflammatory diseases, this review will also focus on the metabolic fate of secretor- and Lewis blood group-specific components. We conclude that there… 
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Human Milk Oligosaccharides: A Comprehensive Review towards Metabolomics
TLDR
A review of the application of metabolomics to investigate the HMOs, by using Pubmed, Researchgate and Scopus as source databases, finds that in the future, this could be possible by using a dipstick and adding the eventual missing oligosaccharide to the breast milk or formula in order to give the best and the most personalized nutritional regimen for each newborn.
Maternal and Infant Factors Associated with Human Milk Oligosaccharides Concentrations According to Secretor and Lewis Phenotypes
TLDR
Unprecedented data on HMOs concentrations from breastfeeding Brazilian women and novel associations of maternal allergic disease and infant’s sex with H MOs concentrations are presented.
Does the contribution of human milk oligosaccharides to the beneficial effects of breast milk allow us to hope for an improvement in infant formulas?
  • J. Chouraqui
  • Medicine
    Critical reviews in food science and nutrition
  • 2020
TLDR
Better understanding of the role of HMOs leading to the development of inexpensive methods for large-scale HMO production is needed, and randomized controlled trials are restricted to structurally simple compounds such as 2’ fucosyllactose and lacto-N-neotetraose.
Human Milk Oligosaccharides: 2′-Fucosyllactose (2′-FL) and Lacto-N-Neotetraose (LNnT) in Infant Formula
TLDR
The limited clinical data suggest that the addition of HMOs to infant formula seems to be safe and well tolerated, inducing a normal growth and suggesting a trend towards health benefits.
In silico analysis of the human milk oligosaccharide glycome reveals key enzymes of their biosynthesis
TLDR
This work adapted a model of mucin-type GalNAc-linked glycosylation enzymes to act on free lactose, identifying a subset of 11 enzyme activities that can account for 206 of 226 distinct HMOs isolated from human milk, and constructed a biosynthetic reaction network that identifies 5 new core HMO structures.
Prebiotics: Mechanisms and Preventive Effects in Allergy
TLDR
Both the mechanisms and the therapeutic evidence from preclinical and clinical studies exploring the role of prebiotics in allergy prevention are described.
Activation of the G-protein coupled receptor GPR35 by human milk oligosaccharides through different pathways
TLDR
A remarkable cooperation between nutrition and microbiota towards activation of a host receptor highlighting the close interplay between environment and host-microbe interactions is demonstrated.
The clinical impact of maternal weight on offspring health: lights and shadows in breast milk metabolome
TLDR
The potential effects of metabolites found altered in breast milk of overweight/obese mothers are investigated, through an extensive review of metabolomics studies, and the potential short- and long-term clinical effects in the offspring are investigated.
Metabolism of Non-Digestible Dietary Carbohydrates
© 2017 Jennifer Williams EFFECTS OF 2ʹ-FUCOSYLLACTOSE ON BRAIN AND COGNITIVE DEVELOPMENT OF INTRAUTERINE GROWTH RESTRICTED PIGLETS BY JENNIFER

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