Composition of the editing complex of Trypanosoma brucei.

@article{Stuart2002CompositionOT,
  title={Composition of the editing complex of Trypanosoma brucei.},
  author={Kenneth D. Stuart and Aswini Kumar Panigrahi and Achim Schnaufer and Maciej Drozdz and Christine Clayton and Reza Salavati},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2002},
  volume={357 1417},
  pages={
          71-9
        }
}
The RNA editing that produces most functional mRNAs in trypanosomes is catalysed by a multiprotein complex. This complex catalyses the endoribonucleolytic cleavage, uridylate addition and removal, and RNA ligation steps of the editing process. Enzymatic and in vitro editing analyses reveal that each catalytic step contributes to the specificity of the editing and, together with the interaction between gRNA and the mRNA, results in precisely edited mRNAs. Tandem mass spectrometric analysis was… CONTINUE READING

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