Composition of Gomori‐positive inclusions in astrocytes of the hypothalamic arcuate nucleus

@article{Brawer1994CompositionOG,
  title={Composition of Gomori‐positive inclusions in astrocytes of the hypothalamic arcuate nucleus},
  author={James R. Brawer and R Stein and Lorne Small and Soriba Ciss{\'e} and Hyman M. Schipper},
  journal={The Anatomical Record},
  year={1994},
  volume={240}
}
Background: Astrocytes within the hypothalamic arcuate nucleus contain Gomori‐positive inclusions that exhibit a nonenzymatic peroxidase activity. The source and composition of these Gomori‐positive inclusions are currently unknown. Recent evidence, derived from cultured astrocytes, suggests that Gomori‐positive inclusions may consist of autophagocytized accumulations of altered mitochondria and that the peroxidase activity is generated by iron or other metals which accumulate in these… 
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This study shows that subcutaneous administration of CSH to adult rats elicits the accumulation of CA in many cortical and subcortical brain regions, and supports the contention that mitochondria are important structural precursors of CA, and that CSH accelerates aging‐like processes in rat astroglia both in vitro and in the intact brain.
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