Composition-based classification of short metagenomic sequences elucidates the landscapes of taxonomic and functional enrichment of microorganisms

@inproceedings{Liu2013CompositionbasedCO,
  title={Composition-based classification of short metagenomic sequences elucidates the landscapes of taxonomic and functional enrichment of microorganisms},
  author={Jiemeng Liu and Haifeng Wang and Hongxing Yang and Yizhe Zhang and Jin-Feng Wang and Fangqing Zhao and Ji Qi},
  booktitle={Nucleic acids research},
  year={2013}
}
Compared with traditional algorithms for long metagenomic sequence classification, characterizing microorganisms' taxonomic and functional abundance based on tens of millions of very short reads are much more challenging. We describe an efficient composition and phylogeny-based algorithm [Metagenome Composition Vector (MetaCV)] to classify very short metagenomic reads (75-100 bp) into specific taxonomic and functional groups. We applied MetaCV to the Meta-HIT data (371-Gb 75-bp reads of 109… CONTINUE READING
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