Composition and three-dimensional architecture of the dengue virus replication and assembly sites.

@article{Welsch2009CompositionAT,
  title={Composition and three-dimensional architecture of the dengue virus replication and assembly sites.},
  author={Sonja Welsch and Sven Miller and In{\'e}s Romero-Brey and Andreas Merz and Christopher Karl Ernst Bleck and Paul Walther and Stephen D. Fuller and Claude Antony and Jacomine Krijnse-Locker and Ralf Bartenschlager},
  journal={Cell host & microbe},
  year={2009},
  volume={5 4},
  pages={365-75}
}
Positive-strand RNA viruses are known to rearrange cellular membranes to facilitate viral genome replication. The biogenesis and three-dimensional organization of these membranes and the link between replication and virus assembly sites is not fully clear. Using electron microscopy, we find Dengue virus (DENV)-induced vesicles, convoluted membranes, and virus particles to be endoplasmic reticulum (ER)-derived, and we detect double-stranded RNA, a presumed marker of RNA replication, inside virus… CONTINUE READING
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