Composition and functional characterization of the yeast spliceosomal penta-snRNP.

@article{Stevens2002CompositionAF,
  title={Composition and functional characterization of the yeast spliceosomal penta-snRNP.},
  author={Scott W. Stevens and Daniel E. Ryan and Helen Y. Ge and Roger E. Moore and Mary K. Young and Terry D. Lee and John Abelson},
  journal={Molecular cell},
  year={2002},
  volume={9 1},
  pages={31-44}
}
Pre-mRNA introns are spliced in a macromolecular machine, the spliceosome. For each round of splicing, the spliceosome assembles de novo in a series of ATP-dependent steps involving numerous changes in RNA-RNA and RNA-protein interactions. As currently understood, spliceosome assembly proceeds by addition of discrete U1, U2, and U4/U6*U5 snRNPs to a pre-mRNA substrate to form functional splicing complexes. We characterized a 45S yeast penta-snRNP which contains all five spliceosomal snRNAs and… CONTINUE READING

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Mentioned Connections BETA
Pre - mRNA introns are spliced in a macromolecular machine , the spliceosome .
Pre - mRNA introns are spliced in a macromolecular machine , the spliceosome .
Pre - mRNA introns are spliced in a macromolecular machine , the spliceosome .
Pre - mRNA introns are spliced in a macromolecular machine , the spliceosome .
Pre - mRNA introns are spliced in a macromolecular machine , the spliceosome .
Pre - mRNA introns are spliced in a macromolecular machine , the spliceosome .
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