Composition and Function of Mutant Swi/Snf Complexes.

  title={Composition and Function of Mutant Swi/Snf Complexes.},
  author={Arnob Dutta and Mihaela E. Sardiu and Madelaine M Gogol and Joshua M. Gilmore and Daoyong Zhang and Laurence Florens and Susan M. Abmayr and Michael P Washburn and Jerry L. Workman},
  journal={Cell reports},
  volume={18 9},
The 12-subunit Swi/Snf chromatin remodeling complex is conserved from yeast to humans. It functions to alter nucleosome positions by either sliding nucleosomes on DNA or evicting histones. Interestingly, 20% of all human cancers carry mutations in subunits of the Swi/Snf complex. Many of these mutations cause protein instability and loss, resulting in partial Swi/Snf complexes. Although several studies have shown that histone acetylation and activator-dependent recruitment of Swi/Snf regulate… CONTINUE READING

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