Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes

  title={Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes},
  author={Marco Mariotti and Perry G. Ridge and Yan Zhang and Alexei V. Lobanov and Thomas H. Pringle and Roderic Guig{\'o} and Dolph Lee Hatfield and Vadim N. Gladyshev},
  booktitle={PloS one},
BACKGROUND Selenium is an essential trace element in mammals due to its presence in proteins in the form of selenocysteine (Sec). Human genome codes for 25 Sec-containing protein genes, and mouse and rat genomes for 24. METHODOLOGY/PRINCIPAL FINDINGS We characterized the selenoproteomes of 44 sequenced vertebrates by applying gene prediction and phylogenetic reconstruction methods, supplemented with the analyses of gene structures, alternative splicing isoforms, untranslated regions, SECIS… CONTINUE READING
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