Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity.

@article{Orr2017CompositionAC,
  title={Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity.},
  author={Brian O. Orr and David A. Gorczyca and Meg A. Younger and Lily Yeh Jan and Yuh-Nung Jan and Graeme W Davis},
  journal={Cell reports},
  year={2017},
  volume={20 8},
  pages={1855-1866}
}
The homeostatic control of presynaptic neurotransmitter release stabilizes information transfer at synaptic connections in the nervous system of organisms ranging from insect to human. Presynaptic homeostatic signaling centers upon the regulated membrane insertion of an amiloride-sensitive degenerin/epithelial sodium (Deg/ENaC) channel. Elucidating the subunit composition of this channel is an essential step toward defining the underlying mechanisms of presynaptic homeostatic plasticity (PHP… CONTINUE READING
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