Composition Influence on Pulmonary Delivery of Rifampicin Liposomes

  title={Composition Influence on Pulmonary Delivery of Rifampicin Liposomes},
  author={Maria Letizia Manca and Chiara Sinico and Anna Maria Maccioni and Octavio D{\'i}ez and Anna Maria Fadda and Maria Manconi},
The effects of lipid concentration and composition on the physicochemical properties, aerosol performance and in vitro toxicity activity of several rifampicin-loaded liposomes were investigated. To this purpose, six liposome formulations containing different amounts of soy phosphatidylcholine and hydrogenated soy phosphatidylcholine, with and without cholesterol and oleic acid, were prepared and fully characterized. Uni- or oligo-lamellar, small (~100 nm), negatively charged (~60 mV) vesicles… CONTINUE READING


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