Composition, variability, and temporal stability of the intestinal microbiota of the elderly.

  title={Composition, variability, and temporal stability of the intestinal microbiota of the elderly.},
  author={Marcus J. Claesson and Siobh{\'a}n Cusack and Orla O'Sullivan and Rachel Greene-Diniz and Heleen H de Weerd and Edel Flannery and Julian R Marchesi and Daniel Falush and Timothy G Dinan and Gerald Fitzgerald and Catherine Stanton and D van Sinderen and Michael H. O'Connor and Norma Harnedy and KIERAN M. O'CONNOR and Colm Henry and Denis O'Mahony and Anthony P. Fitzgerald and F Shanahan and Cillian Twomey and C. Ray Hill and R Paul Ross and Paul W O'Toole},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 Suppl 1},
Alterations in the human intestinal microbiota are linked to conditions including inflammatory bowel disease, irritable bowel syndrome, and obesity. The microbiota also undergoes substantial changes at the extremes of life, in infants and older people, the ramifications of which are still being explored. We applied pyrosequencing of over 40,000 16S rRNA gene V4 region amplicons per subject to characterize the fecal microbiota in 161 subjects aged 65 y and older and 9 younger control subjects… CONTINUE READING
Highly Influential
This paper has highly influenced 20 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 381 extracted citations


Publications referenced by this paper.
Showing 1-10 of 52 references

Gut microbiota: Changes throughout the lifespan from infancy to elderly

  • PW O’Toole, MJ Claesson
  • Int Dairy J 20:281–291
  • 2010

Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine

  • MJ Claesson
  • PLoS ONE 4:e6669
  • 2009

Development and application of the human intestinal tract chip, a phylogenetic microarray: Analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults

  • M Rajilić-Stojanović
  • Environ Microbiol
  • 2009

Similar Papers

Loading similar papers…