Components of the Ligand for a Ni++ Reactive Human T Cell Clone

@article{Lu2003ComponentsOT,
  title={Components of the Ligand for a Ni++ Reactive Human T Cell Clone},
  author={Linh Khanh Lu and Joerg Vollmer and Corinne Moulon and Hans Ulrich Weltzien and Philippa Marrack and John W Kappler},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={197},
  pages={567 - 574}
}
The major histocompatibility complex (MHC) restriction element for a human Ni(2+) reactive T cell, ANi-2.3, was identified as DR52c. A series of experiments established that the functional ligand for this T cell was a preformed complex of Ni(2+) bound to the combination of DR52c and a specific peptide that was generated in human and mouse B cells, but not in fibroblasts nor other antigen processing-deficient cells. In addition, ANi-2.3 recognition of this complex was dependent on His81 of the… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

The specificity of TCR/pMHC interaction.