Biologicheskaya bezopasnost’ v sovremennom mire: Materialy nauch
- E. M. Kuznetsova, O. A. Volokh, Shepelev, I.A
- prakt. konf. (Biosafety in the Modern World: Proc…
The study presents the structural characteristics of the Francisella tularensis protective antigen complex (PAC)—a water-soluble antigen of the outer membrane (OMs) of the tularemia microorganism with a complex chemical nature with molecular mass of about 280 kDa. The immunochemically active subunits of the antigen protective complex with molecular masses from 81 to 19 kDa are established as having a protein nature, and those with 14–17 kDa are of lipoprotein nature. Stress chaperones (GroES and GroEL), the OM proteins (FRL_0617 and OmpH), regulatory proteins (EF-Tu and RplL), and bacterial enzymes (KatG and GAPDH) and a lipopolysaccharide were indentified in the PAC, which are responsible for its high immunobiological activity.