Components of neuronal chloride transport in rat and human neocortex.

  title={Components of neuronal chloride transport in rat and human neocortex.},
  author={Rudolf A Deisz and Thomas-N Lehmann and Peter Horn and C. Dehnicke and Robert Nitsch},
  journal={The Journal of physiology},
  volume={589 Pt 6},
Considerable evidence indicates disturbances in the ionic gradient of GABAA receptor-mediated inhibition of neurones in human epileptogenic tissues. Two contending mechanisms have been proposed, reduced outward and increased inward Cl⁻ transporters. We investigated the properties of Cl⁻ transport in human and rat neocortical neurones (layer II/III) using intracellular recordings in slices of cortical tissue. We measured the alterations in reversal potential of the pharmacologically isolated… CONTINUE READING


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