Components of Panax notoginseng saponins enhance the cytotoxicity of cisplatin via their effects on gap junctions.

  title={Components of Panax notoginseng saponins enhance the cytotoxicity of cisplatin via their effects on gap junctions.},
  author={Cui-ling Zhang and X. Tong and Benquan Qi and X. Yu and Shu-ying Dong and Suzhi Zhang and Xiaoming Li and Meiling Yu},
  journal={Molecular medicine reports},
  volume={8 3},
Previously, Panax notoginseng saponin (PNS)-induced enhancement of gap junction (GJ) formation or function was observed to be responsible for the increased cytotoxic action of cisplatin. PNS has three constituents, ginsenoside Rg1 and Rb1, and notoginsenoside R1. The active compounds in PNS responsible for enhancing the cytotoxicity of cisplatin remain unknown. Thus, the effects of the main components of PNS on the cytotoxicity of cisplatin were investigated, as well as the correlation with the… Expand
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Panax notoginseng saponins ameliorate cisplatin‐induced mitochondrial injury via the HIF‐1α/mitochondria/ROS pathway
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DDDT_A_240511 551..565
Hai Liu 1,2 Jianqiong Yang 3 Wanqing Yang Shaonan Hu 1 Yali Wu 1 Bo Zhao 1 Haiyan Hu 1 Shouying Du 1 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’sExpand
Bioactivity of Steroid and Triterpenoid Saponins: Influence on Membrane Permeability and Drug Absorption
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Panax notoginseng saponins enhances the cytotoxicity of cisplatin via increasing gap junction intercellular communication.
It is suggested that PNS increases the cytotoxicity of cisplatin through enhancement of GJ activity in a dose-dependent manner. Expand
Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells.
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Tramadol and Flurbiprofen Depress the Cytotoxicity of Cisplatin via Their Effects on Gap Junctions
It is indicated that tramadol and flurbiprofen depress cisplatin cytotoxicity through inhibition of gap junction activity, and more generally, that agents that depress junctional communication can counteract the effects of antitumor agents. Expand
Cisplatin and Oxaliplatin Inhibit Gap Junctional Communication by Direct Action and by Reduction of Connexin Expression, Thereby Counteracting Cytotoxic Efficacy
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Gap junctions propagate opposite effects in normal and tumor testicular cells in response to cisplatin.
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Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions.
  • R. Jensen, P. Glazer
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
It is shown that there is a separate cell-interdependent pathway of cisplatin killing in which damaged cells can transmit a death signal to neighboring cells, suggesting that DNA-dependent protein kinase activity and gap junction expression in human cancers may influence the clinical response to cis platin. Expand