Complications of tumor necrosis factor-α blockade in chronic granulomatous disease-related colitis.

  title={Complications of tumor necrosis factor-α blockade in chronic granulomatous disease-related colitis.},
  author={Gulbu Uzel and Jordan S Orange and Nina Poliak and Beatriz E. Marciano and Theo Heller and Steven M Holland},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  volume={51 12},
BACKGROUND Chronic granulomatous disease (CGD) is a genetic disorder of the phagocyte NADPH oxidase, which predisposes patients to infections and inflammatory complications, including severe colitis. Management of CGD colitis is a challenge because standard immunosuppressive therapy increases the risk of infection in already immunocompromised hosts. METHODS We report the use of infliximab in 5 patients with CGD. RESULTS Infliximab administration predisposed patients to severe infections… CONTINUE READING


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