Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery.

@article{Nussmeier2005ComplicationsOT,
  title={Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery.},
  author={Nancy A. Nussmeier and Andrew A Whelton and Mark T. Brown and Richard M. Langford and Andreas Hoeft and Joel L. Parlow and Steven W. Boyce and Kenneth M. Verburg},
  journal={The New England journal of medicine},
  year={2005},
  volume={352 11},
  pages={
          1081-91
        }
}
BACKGROUND Valdecoxib and its intravenous prodrug parecoxib are used to treat postoperative pain but may involve risk after coronary-artery bypass grafting (CABG). We conducted a randomized trial to assess the safety of these drugs after CABG. METHODS In this randomized, double-blind study involving 10 days of treatment and 30 days of follow-up, 1671 patients were randomly assigned to receive intravenous parecoxib for at least 3 days, followed by oral valdecoxib through day 10; intravenous… 

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