Complications associated with genetic background effects in models of experimental epilepsy.

@article{Schauwecker2002ComplicationsAW,
  title={Complications associated with genetic background effects in models of experimental epilepsy.},
  author={Paula Elyse Schauwecker},
  journal={Progress in brain research},
  year={2002},
  volume={135},
  pages={139-48}
}
To elucidate the genetic influences contributing to susceptibility to seizure disorders, researchers have long used selected lines and inbred strains of rodents. In recent years, the use of genetically altered mice as models of complex human disease has revolutionized biomedical research into the genetics of disease pathogenesis and potential therapeutic interventions. In particular, the study of transgenic and gene-deleted (knockout) mice can provide important insights into the in vivo… CONTINUE READING

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