Complications and limitations of drug therapy for Parkinson's disease.

@article{Jankovic2000ComplicationsAL,
  title={Complications and limitations of drug therapy for Parkinson's disease.},
  author={Joseph Jankovic},
  journal={Neurology},
  year={2000},
  volume={55 12 Suppl 6},
  pages={S2-6}
}
Levodopa is the most effective drug treatment for Parkinson's disease (PD). However, its chronic use is associated with dyskinesia, motor fluctuations, and hallucinations. There are various approaches to the management of levodopa complications. Motor fluctuations can be treated with a long-acting levodopa preparation, liquid levodopa, or the addition of dopamine agonists or catechol-O-methyl transferase (COMT) inhibitors. Drugs that may improve levodopa-induced psychiatric complications are… CONTINUE READING

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