Complexity of human T-cell antigen receptor β-chain constant- and variable-region genes

@article{Sims1984ComplexityOH,
  title={Complexity of human T-cell antigen receptor β-chain constant- and variable-region genes},
  author={J. E. Sims and Alan Tunnacliffe and Wendy J M Smith and Terence H Rabbitts},
  journal={Nature},
  year={1984},
  volume={312},
  pages={541-545}
}
Immune systems of vertebrates function via two types of effector cells, B and T cells, which are capable of antigen-specific recognition. The immunoglobulins, which serve as antigen receptors on B cells, have been well characterized with respect to gene structure1, unlike the T-cell receptors. Recently, cDNA clones thought to correspond to the β-chain locus2–4 of the human and mouse T-cell receptor have been described. The presumptive β-chain clones detect gene rearrangement specifically in T… CONTINUE READING
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