Complexity of calcium signaling in synaptic spines.

  title={Complexity of calcium signaling in synaptic spines.},
  author={Kevin M. Franks and Terrence J. Sejnowski},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={24 12},
Long-term potentiation and long-term depression are thought to be cellular mechanisms contributing to learning and memory. Although the physiological phenomena have been well characterized, little consensus of their underlying molecular mechanisms has emerged. One reason for this may be the under-appreciated complexity of the signaling pathways that can arise if key signaling molecules are discretely localized within the synapse. Recent findings suggest an unanticipated degree of structural… CONTINUE READING
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