Complexity of botulinum neurotoxins: challenges for detection technology.

@article{Dorner2012ComplexityOB,
  title={Complexity of botulinum neurotoxins: challenges for detection technology.},
  author={Martin Bernhard Dorner and Kathleen M. Schulz and Skadi Kull and Brigitte G Dorner},
  journal={Current topics in microbiology and immunology},
  year={2012},
  volume={364},
  pages={
          219-55
        }
}
The detection of botulinum neurotoxins (BoNT) is extremely challenging due to their high toxicity and the multiple BoNT variants. To date, seven serotypes with more than 30 subtypes have been described, and even more subtypes are expected to be discovered. The fact that the BoNT molecules are released as large complexes of different size and composition adds further complexity to the issue. Currently, in the diagnostics of botulism, the mouse bioassay (MBA) is still considered as gold standard… CONTINUE READING
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