Complexity in the care of elderly patients and polypharmacy.


treatment was interrupted because of the development of a primaquine induced methemoglobinemia. We switched to intravenous pentamidine with success and the patient was discharged after 2 weeks. The prevalence of clinically-significant cryoglobulinemia (CG) has been estimated at approximately 1:100,000. A combination of polyclonal immunoglobulin in association with a monoclonal immunoglobulin, classically IgM or IgA endowed with RF activity, defines type II cryoglobulinemia. It accounts for approximately 40 to 60% of CGs. Type II CGs are often due to persistent viral infections, particularly hepatitis C and HIV [1,2]. In our case, such infection was ruled out and resolution of both eruption and CG after cotrimoxazole interruption is an argument for a drug induced mixed cryoglobulinemia.

DOI: 10.1016/j.ejim.2007.09.009

Cite this paper

@article{Nardi2008ComplexityIT, title={Complexity in the care of elderly patients and polypharmacy.}, author={Roberto Nardi and Giovanni Scanelli}, journal={European journal of internal medicine}, year={2008}, volume={19 4}, pages={304} }