Identifying High-Cost, High-Risk Patients Using Administrative Databases in Tuscany, Italy
treatment was interrupted because of the development of a primaquine induced methemoglobinemia. We switched to intravenous pentamidine with success and the patient was discharged after 2 weeks. The prevalence of clinically-significant cryoglobulinemia (CG) has been estimated at approximately 1:100,000. A combination of polyclonal immunoglobulin in association with a monoclonal immunoglobulin, classically IgM or IgA endowed with RF activity, defines type II cryoglobulinemia. It accounts for approximately 40 to 60% of CGs. Type II CGs are often due to persistent viral infections, particularly hepatitis C and HIV [1,2]. In our case, such infection was ruled out and resolution of both eruption and CG after cotrimoxazole interruption is an argument for a drug induced mixed cryoglobulinemia.