Complexity in simplicity: monogenic disorders and complex cardiomyopathies.

@article{Chen1999ComplexityIS,
  title={Complexity in simplicity: monogenic disorders and complex cardiomyopathies.},
  author={J Y Chen and Kenneth R. Chien},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={103 11},
  pages={1483-5}
}
complex human diseases has never been a simple task. A prime example of the challenge of complex diseases is offered by reflecting on the breathtak-ing advances in our understanding of the pathways that lead to human car-diomyopathies. Cardiomyopathies have traditionally been considered to represent diseases that primarily affect cardiac muscle, although in many cases cardiac dysfunction arises due to a secondary effect on the heart from an initial insult outside of cardiac muscle per se. As… CONTINUE READING
32 Citations
13 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 13 references

Gamma - sarcoglycan deficiency leads to muscle membrane defects and apoptosis independent of dystrophin

  • A. A. Hack
  • J . Cell Biol .
  • 1998

Similar Papers

Loading similar papers…