Complexity in simplicity: monogenic disorders and complex cardiomyopathies.

  title={Complexity in simplicity: monogenic disorders and complex cardiomyopathies.},
  author={J Y Chen and Kenneth R. Chien},
  journal={The Journal of clinical investigation},
  volume={103 11},
complex human diseases has never been a simple task. A prime example of the challenge of complex diseases is offered by reflecting on the breathtak-ing advances in our understanding of the pathways that lead to human car-diomyopathies. Cardiomyopathies have traditionally been considered to represent diseases that primarily affect cardiac muscle, although in many cases cardiac dysfunction arises due to a secondary effect on the heart from an initial insult outside of cardiac muscle per se. As… CONTINUE READING
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