Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation.

  title={Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation.},
  author={Beno{\^i}t Salomon and Jeffrey A Bluestone},
  journal={Annual review of immunology},
Recent advances in the understanding of T cell activation have led to new therapeutic approaches in the treatment of immunological disorders. One attractive target of intervention has been the blockade of T cell costimulatory pathways, which result in more selective effects on only those T cells that have encountered specific antigen. In fact, in some instances, costimulatory pathway antagonists can induce antigen-specific tolerance that prevents the progression of autoimmune diseases and organ… CONTINUE READING
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