Complexin II is essential for normal neurological function in mice.

  title={Complexin II is essential for normal neurological function in mice.},
  author={Dervila Glynn and Rachel A. Bortnick and A. Jennifer Morton},
  journal={Human molecular genetics},
  volume={12 19},
Complexins (CPLXs) are modulators of synaptic vesicle release. At 1 year of age, CPLXII knockout (KO) mice appear normal. However, behavioral testing reveals underlying deficits of motor and cognitive function in these mice. We found motor deficits on the rotarod, and learning deficits in the Morris water maze (both acquisition and reversal) and the two-choice swim tank (reversal). The reversal learning deficits are particularly noticeable, being present from the earliest time of testing, when… CONTINUE READING


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Reduced hippocampal LTP in mice lacking a presynaptic protein: complexin II.

The European journal of neuroscience • 1999
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