Complexin I knockout rats exhibit a complex neurobehavioral phenotype including profound ataxia and marked deficits in lifespan

@article{Xu2019ComplexinIK,
  title={Complexin I knockout rats exhibit a complex neurobehavioral phenotype including profound ataxia and marked deficits in lifespan},
  author={Yang Xu and Xiao-Ming Zhao and Jia Liu and Yang-Yang Wang and Liulin Xiong and Xiu-Ying He and T. Wang},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2019},
  volume={472},
  pages={117-133}
}
Complexin I (CPLX1), a presynaptic small molecule protein, forms SNARE complex in the central nervous system involved in the anchoring, pre-excitation, and fusion of axonal end vesicles. Abnormal expression of CPLX1 occurs in several neurodegenerative and psychiatric disorders that exhibit disrupted neurobehaviors. CPLX1 gene knockout induces severe ataxia and social behavioral deficits in mice, which has been poorly demonstrated. Here, to address the limitations of single-species models and to… Expand

References

SHOWING 1-10 OF 58 REFERENCES
Complexin 1 knockout mice exhibit marked deficits in social behaviours but appear to be cognitively normal.
Complexin II is essential for normal neurological function in mice.
Early motor development is abnormal in complexin 1 knockout mice
A Novel Transgenic Rat Model for Spinocerebellar Ataxia Type 17 Recapitulates Neuropathological Changes and Supplies In Vivo Imaging Biomarkers
A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype.
Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice
Regional and progressive changes in brain expression of complexin II in a mouse transgenic for the Huntington’s Disease mutation
...
1
2
3
4
5
...