Complexin Clamps Asynchronous Release by Blocking a Secondary Ca2+ Sensor via Its Accessory α Helix

@article{Yang2010ComplexinCA,
  title={Complexin Clamps Asynchronous Release by Blocking a Secondary Ca2+ Sensor via Its Accessory α Helix},
  author={Xiaofei Yang and Yea Jin Kaeser-Woo and Zhiping P Pang and Wei Xu and Thomas C S{\"u}dhof},
  journal={Neuron},
  year={2010},
  volume={68},
  pages={907-920}
}
Complexin activates and clamps neurotransmitter release; impairing complexin function decreases synchronous, but increases spontaneous and asynchronous synaptic vesicle exocytosis. Here, we show that complexin-different from the Ca(2+) sensor synaptotagmin-1-activates synchronous exocytosis by promoting synaptic vesicle priming, but clamps spontaneous and asynchronous exocytosis-similar to synaptotagmin-1-by blocking a secondary Ca(2+) sensor. Activation and clamping functions of complexin… CONTINUE READING
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