Complexin-1 Enhances the On-Rate of Vesicle Docking via Simultaneous SNARE and Membrane Interactions

@inproceedings{Diao2013Complexin1ET,
  title={Complexin-1
Enhances the On-Rate of Vesicle
Docking via Simultaneous SNARE and Membrane Interactions},
  author={Jiajie Diao and Daniel J. Cipriano and Minglei Zhao and Yunxiang Zhang and Sachi N. Shah and Mark S. Padolina and Richard A Pfuetzner and Axel T Brunger},
  booktitle={Journal of the American Chemical Society},
  year={2013}
}
In synaptic terminals, complexin is thought to have inhibitory and activating roles for spontaneous "mini" release and evoked synchronized neurotransmitter release, respectively. We used single vesicle-vesicle microscopy imaging to study the effect of complexin-1 on the on-rate of docking between vesicles that mimic synaptic vesicles and the plasma membrane. We found that complexin-1 enhances the on-rate of docking of synaptic vesicle mimics containing full-length synaptobrevin-2 and full… CONTINUE READING

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