Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM.

@article{Fallang2008ComplexesOT,
  title={Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM.},
  author={L E Fallang and Sujin Roh and Anders Holm and Elin Bergseng and Taejin Yoon and Burkhard Fleckenstein and Arunima Bandyopadhyay and Elizabeth D Mellins and Ludvig M. Sollid},
  journal={Journal of immunology},
  year={2008},
  volume={181 8},
  pages={5451-5461}
}
Atypical invariant chain (Ii) CLIP fragments (CLIP2) have been found in association with HLA-DQ2 (DQ2) purified from cell lysates. We mapped the binding register of CLIP2 (Ii 96-104) to DQ2 and found proline at the P1 position, in contrast to the canonical CLIP1 (Ii 83-101) register with methionine at P1. CLIP1/2 peptides are the predominant peptide species, even for DQ2 from HLA-DM (DM)-expressing cells. We hypothesized that DQ2-CLIP1/2 might be poor substrates for DM. We measured DM-mediated… CONTINUE READING