Complexes of immunoglobulins A and G with aspartate aminotransferase isoenzymes in serum.

@article{Nagamine1983ComplexesOI,
  title={Complexes of immunoglobulins A and G with aspartate aminotransferase isoenzymes in serum.},
  author={Makiko Nagamine and Kazuo Okochi},
  journal={Clinical chemistry},
  year={1983},
  volume={29 2},
  pages={379-81}
}
We report the presence of complexes between aspartate aminotransferase (AST, EC 2.6.1.1) and immunoglobulin (Ig) in the serum of a patient suffering from lung cancer with metastasis to the liver. After fractionation of the serum by gel filtration, AST-Ig complexes (AST-IgA, AST-IgG) were demonstrated by counterimmunoelectrophoresis. Dissociating the complexes and recombining them with purified isoenzyme fractions, s-AST (cytoplasmic) and m-AST (mitochondrial), revealed that only s-AST binds to… CONTINUE READING
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