Complexation of norfloxacin with DNA in the presence of caffeine.

@article{Evstigneev2006ComplexationON,
  title={Complexation of norfloxacin with DNA in the presence of caffeine.},
  author={Maxim P Evstigneev and Kristina A. Rybakova and David Bradley Davies},
  journal={Biophysical chemistry},
  year={2006},
  volume={121 2},
  pages={
          84-95
        }
}
(1)H NMR spectroscopy (500 MHz) has been used to quantify the complexation of the antibacterial antibiotic Norfloxacin (NOR) with DNA in the presence of Caffeine (CAF). Separate studies have been made for the self-association of NOR, its hetero-association with CAF and complexation with a model self-complementary DNA tetramer, 5'-d(TpGpCpA), in order to determine the equilibrium parameters (induced chemical shifts, association constants, enthalpy and entropy) of the two-component mixtures to… CONTINUE READING
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