Complexation of iron cation by sodium urate crystals and gouty inflammation.

  title={Complexation of iron cation by sodium urate crystals and gouty inflammation.},
  author={Andrew J Ghio and Thomas P Kennedy and Govind Rao and Cara L. Cooke and Marvin J Miller and John R. Hoidal},
  journal={Archives of biochemistry and biophysics},
  volume={313 2},
Gouty inflammation can be suppressed by an iron chelator. We therefore hypothesized that arthritis associated with sodium urate crystal deposition could follow the incomplete complexation of iron cation with subsequent oxidant generation as the metal cycles through reduced and oxidized states. Urate crystals adsorbed Fe3+ in vitro and crystals collected from a human tophus had significant concentrations of ionizable iron. Urate crystals oxidized deoxyribose to a thiobarbituric acid (TBA… CONTINUE READING
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