Complexation as an approach to entrap cationic drugs into cationic nanoparticles administered intranasally for Alzheimer's disease management: preparation and detection in rat brain

@article{Hanafy2015ComplexationAA,
  title={Complexation as an approach to entrap cationic drugs into cationic nanoparticles administered intranasally for Alzheimer's disease management: preparation and detection in rat brain},
  author={Amira Sayed Hanafy and Ragwa Mohamed Farid and Safaa S ElGamal},
  journal={Drug Development and Industrial Pharmacy},
  year={2015},
  volume={41},
  pages={2055 - 2068}
}
Abstract Objective: Complexation was investigated as an approach to enhance the entrapment of the cationic neurotherapeutic drug, galantamine hydrobromide (GH) into cationic chitosan nanoparticles (CS-NPs) for Alzheimer’s disease management intranasally. Biodegradable CS-NPs were selected due to their low production cost and simple preparation. The effects of complexation on CS-NPs physicochemical properties and uptake in rat brain were examined. Methods: Placebo CS-NPs were prepared by ionic… 
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Pharmacological, toxicological and neuronal localization assessment of galantamine/chitosan complex nanoparticles in rats: future potential contribution in Alzheimer’s disease management
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How chitosan-based NPs could be used to address current challenges in the treatment of AD is reviewed; with a specific focus on the enhancement of blood-brain barrier penetration of anti-Alzheimer drugs and on the reduction of their peripheral side effects.
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The prepared nanoparticle gel can be an effective controlled release system of TM that administered topically on the skin surface that showed a sustained release manner within 24 h by following Korsmeyer–Peppas kinetical model with non-Fickian release mechanism.
Intranasal galantamine/chitosan complex nanoparticles elicit neuroprotection potentials in rat brains via antioxidant effect
TLDR
Intranasal GH/chitosan complex nanoparticles (CX-NP2) show promising potential as a brain targeting carrier and induce a statistically significant oxidative stress or neuroinflammation in rat brains after 30-day treatment but elicited neuroprotective potentials.
Optimization of Galantamine Loaded Bovine Serum Albumin Nanoparticles by Quality by Design and Its Preliminary Characterizations
Alzheimer’s disease is a progressive neurodegenerative disorder having a severe socio-economical and medical burden all over the world. The objective of this work was to develop nanoparticulate drug…
Glutaraldehyde-crosslinked chitosan-polyethylene oxide nanofibers as a potential gastroretentive delivery system of nizatidine for augmented gastroprotective activity
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Solid-state characterization indicated polymers interaction, a successful crosslinking, and NIZ dispersion in NFs, which preserved the gastric wall architecture, COX-2 expression, and oxidative stress markers levels of the normal rats.
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Pharmacological, toxicological and neuronal localization assessment of galantamine/chitosan complex nanoparticles in rats: future potential contribution in Alzheimer’s disease management
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