Complex translocation [7;22] identified in an epithelioid hemangioendothelioma.

Abstract

We describe a malignant epithelioid hemangioendothelioma arising in the back of a 45-year-old man with pulmonary and bone marrow metastases. Light microscopic and immunohistochemical features of this tumor are presented. Karyotyping revealed several clonal abnormalities: a complex unbalanced translocation [7;22] involving multiple breakpoints (confirmed by fluorescence in situ hybridization), a Robertsonian t(14;14), and loss of the Y chromosome. Monosomy for chromosome 11 was noted in a subset of the tumor cells. To our knowledge a karyotype has not been previously reported for this unusual vascular tumor.

0200400600'99'01'03'05'07'09'11'13'15'17
Citations per Year

1,395 Citations

Semantic Scholar estimates that this publication has 1,395 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Boudousquie1996ComplexT, title={Complex translocation [7;22] identified in an epithelioid hemangioendothelioma.}, author={Alan C Boudousquie and Helen J. Lawce and Rachel M Sherman and Susan B. Olson and R. Ellen Magenis and Christopher Corless}, journal={Cancer genetics and cytogenetics}, year={1996}, volume={92 2}, pages={116-21} }