Complex trait locus linkage mapping in atherosclerosis: time to take a step back before moving forward?

@article{Pollex2005ComplexTL,
  title={Complex trait locus linkage mapping in atherosclerosis: time to take a step back before moving forward?},
  author={Rebecca L. Pollex and Robert A Hegele},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2005},
  volume={25 8},
  pages={1541-4}
}
E ver since the initial proposal to use polymorphic DNA markers to map genetic diseases,1 linkage analysis (also called “positional cloning”) has been used successfully to find the gene defects for hundreds of monogenic Mendelian traits.2 Because monogenic diseases can serve as important models for understanding pathogenesis, especially if they point to novel biochemical and physiological pathways, linkage analysis has revolutionized biomedicine. A prime example of the success of linkage… CONTINUE READING
Highly Cited
This paper has 19 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Predictive genetic testing for coronary artery disease.

Critical reviews in clinical laboratory sciences • 2009
View 1 Excerpt

Genetic determinants of the metabolic syndrome

Nature Clinical Practice Cardiovascular Medicine • 2006

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Lack of MEF2A mutations in coronary artery disease.

The Journal of clinical investigation • 2005

Similar Papers

Loading similar papers…